Investigation of Vitamin B12 Deficiency in Patients with Type 2 Diabetes Mellitus Using Metformin
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https://doi.org/10.5281/zenodo.7395545Keywords:
Metformin, Type 2 DM, Vitamin B12Abstract
Aim: In this study, we aimed to investigate the change in vitamin B12 levels at the end of 6-month follow-up in patients who were diagnosed with type 2 DM after applying to the outpatient clinic of Kafkas University and were started on metformin treatment.
Materials and Methods: 101 patients who applied to Kafkas University Health Research and Application Hospital Family Medicine and Internal Diseases Polyclinics between 01.06.2019-01.06.2020 (1 year period) and were diagnosed with type 2 DM as a result of anamnesis, physical examination and blood tests and started metformin as treatment, were included in the study. was included.
Results: Of the patients included in the study, 63 (62.4%) were female and 38 (37.6%) were male. These patients were followed up for a period of 6 months, and vitamin B12 and other requested tests (laboratory tests) were evaluated in the study.
Conclusion: In our study on patients who were started on metformin considering type 2 DM, we found that there was a statistically significant decrease in vitamin B12 levels in the 6-month follow-up period. Based on our study, we state that vitamin B12 levels should be monitored in patients with type 2 DM who were started on metformin therapy, and we emphasize the necessity of prompt replacement in patients with vitamin B12 deficiency.
References
Ahmed MA. Metformin and Vitamin B12 Deficiency: Where Do We Stand? J Pharm Pharm Sci. 2016; 19(3):382-398.
Ahmed MA, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacol Toxicol. 2016;17-44.
Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, et al. Diabetes Prevention Program Research Group. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab. 2016; 101:1754-61.
Beulens JW, Hart HE, Kuijs R, Kooijman-Buiting AM, Rutten GE. Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol. 2015;52:47–53
De Groot-Kamphuis DM, van Dijk PR, Groenier KH, Houweling ST, Bilo HJ, Kleefstra N. Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin. Neth J Med. 2013;71:386–390.
De Jager J, Kooy A, Lehert P, Wulffele MG, van der Kolk J, Bets D, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B12 deficiency: randomised placebo controlled trial. BMJ 2010 May 20;340:c2181.
Duru, H. (a). The prevalence and severity of mental health problems and sexual dysfunction in hemodialysis patients before and during the COVID-19pandemic. TherApher Dial. 2022; 1– 9.
Duru H. (b). The Continuing Effect of COVID-19 Pandemic on Physical Well-Being and Mental Health of ICU Healthcare Workers in Turkey: A Single-Centre Cross-Sectional Later-Phase Study. Journal of Intensive Care Medicine. 2022;37(9):1206-1214.
Fletcher B, Gulanick M, Lamendola C. Risk factors for type 2 diabetes mellitus. J Cardiovasc Nurs. 2002 Jan;16(2):17-23.
Haeusler S, Parry-Strong A, Krebs JD. The prevalence of low vitamin B12 status in people with type 2 diabetes receiving metformin therapy in New Zealand–a clinical audit. N Z Med J. 2014;127:8–16.
Hilawe EH, Yatsuya H, Leo Kawaguchia L, Aoyamaa A. Differences by sex in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan Africa: a systematic review and meta-analysis.Bull World Health Organ 2013;91:671–682D.
Kanter R, Caballero B. (2012). Global gender disparities in obesity: a review. Adv Nutr 3(4):491–8.10.3945/an.112.002063
Kautzky-Willer A, Kosi L, Lin J, Mihaljevic R. Gender-based differences in glycaemic control and hypoglycaemia prevalence in patients with type 2 diabetes: results from patient-level pooled data of six randomized controlled trials. Diabetes Obes Metab. 2015;17(6):533-540.
Ko SH, Ko SH, Ahn YB, et al. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. J Korean Med Sci. 2014;29:965–972.
Liu Q, Li S, Quan H, Li J. Vitamin B12 status in metformin treated patients: systematic review. PLoS One. 2014; 24:e100379.
Nervo M, Lubini A, Raimundo FV, et al. Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil. Rev Assoc Med Bras. 2011;57:46–49.
Pflipsen MC, Oh RC, Saguil A, Seehusen DA, Seaquist D, Topolski R. The prevalence of vitamin B(12) deficiency in patients with type 2 diabetes: a cross-sectional study. J Am Board Fam Med. 2009;22:528–534.
Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP,Jr. Association of biochemical B(12) deficiency with metformin therapy and vitamin B(12) supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care .2012;35: 327-333.
Tomkin GH, Hadden DR, Weaver JA, Montgomery DA. Vitamin-B12 status of patients on long-term metformin therapy. Br Med J. 1971; 685-7.
Schiebinger L, Klinge I, Sánchez de Madariaga I, Paik H, Schraudner M, Stefanick M. Gendered innovations in science, health, medicine, engineering and environment.2011–2015.Available at http://gender edinnovations .stanford. edu/ Accessed January 10, 2015.
Wardle J, Haase AM, Steptoe A, Nillapun M, Jonwutiwes K, Bellisle F. Gender differences in food choice: the contribution of health beliefs and dieting. Ann Behav Med (2004) 27(2):107–16.10.1207/s15324796abm2702_5
Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018; 14 :88-98.
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