Determination of the Effects of Serum Fe, Cu, Zn Levels and Cu / Zn Ratio In Development of Migraine Disease
Abstract views: 166
/ 
PDF downloads: 114
DOI:
https://doi.org/10.5281/zenodo.7388264Keywords:
migraine, iron, traceelements, copper, zinc, atomicabsorptionspectrophotometryAbstract
Objectıve: The purpose of this study is to determine the effects of the relationships between serum Fe, Cu, Zn levels, Cu / Zn ratio and parameters related to migraine pathogenesis in the development of migraine disease.
Material and Methods: Serum Fe, Cu and Zn trace element levels were determined using atomic absorption spectrophotometer method.
Results: Serum Cu levels (p<0.001), serum Zn levels (p=0.019) were determined significantly higher in the migraine patient group than control group. In our study, it was determined that strong negative correlation between serum Zn value and Cu / Zn value (r= -0.755; p<0.001).
Conclusion: In our study, it was determined that disorders in serum Fe, Cu and Zn homeostasis may be effective in the development of migraine. Thus, it is very important to evaluate together serum Fe, Cu, Zn levels in the pathogenesis of migraine and the parameters related to the mechanisms that may contribute to the development of migraine in order to obtain important biomarkers for the diagnosis and treatment of migraine.
References
Acar, A., Evliyaoğlu, O., Uzar, E., Yücel, Y., Çevik, M.U., Güzel, I.,…, Taşdemir, N. (2011). Serum vitamin B12, folic acid and ferritin levels in patients with migraine. Turk J Neurol, 17(2), 90-95
Ahmadi, H., Mazloumi-Kiapey, S.S., Sadeghi, O., Nasiri, M., Khorvash, F., Mottaghi, T., Askari, G. (2020). Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial. Nutr J, 19(101).
Beard, J.L., Felt, B., Schallert, T., Burhans, M., Connor, J.R., Georgieff, M.K. (2016). Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res, 170(2), 224-32.
Blumenfeld, A.M., Varon, S.F., Wilcox, T.K., Buse, D.C., Kawata, A.K., Manack, A.,…, Lipton, R.B. (2011). Disability, HRQoL and resource use among chronic and episodic migraineurs: results from the International Burden of Migraine Study (IBMS). Cephalalgia, 31(3), 301-15.
Charles, A. (2018). The pathophysiology of migraine: implications for clinical management. Lancet Neurol, 17(2), 174-82
Gonullu, H., Gonullu, E., Karadas, S., Arslan, M., Kalemci, O., Aycan, A.,…,Demir, H. (2015). The levels of trace elements and heavy metals in patients with acute migraine headache. J Pak Med Assoc, 65(7), 694-7.
Lozoff, B. (2011). Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction. J Nutr, 141(4), 740-6.
Matak, P., Matak, A., Moustafa, S., Aryal, D.K., Benner, E.J., Wetsel, W., Andrews, N.C. (2016). Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A, 113(13), 3428-35.
Mazaheri, M., Aghdam, A.M., Heidari, M., Zarrin, R. (2021). Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res, 10(2), 127-139.
Meng, S.H., Zhou, H.B., Li, X., Wang, M.X., Kang, L.X., Fu, J.M.,…,Zhao YS. (2021). Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine. Front Nutr, 8, 685564.
Osredkar, J., Sustar, N. (2011). Copper and Zinc, Biological Role and Significance of Copper/Zinc Imbalance. J Clinic Toxicol, S3, 001.
Styczeń, K., Sowa-Kućma, M., Siwek, M., Dudek, D., Reczyński, W., Misztak, P.,…,Nowak, G. (2016). Study of the Serum Copper Levels in Patients with Major Depressive Disorder. Biol Trace Elem Res, 174(2), 287-293.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The journal is licensed under a 