The Effects of The Bongardia Chrysogonum (L) In A Rat Model of Diabetic Nephropathy

Abstract

Diabetic nephropathy is increasing in frequency and is one of the most important causes of end-stage renal disease. In this study, the effect of Bongardia chrysogonum on kidneys by induced diabetic nephropathy in a diabetic rat model induced by streptozotocin (STZ) was investigated. Forty male Wistar Albino rats were used in the study. Rats; They were divided into 4 groups as the control group (K), the group given B. chrysogonum (B), the group with diabetes (DM) and the group given B. chrysogonum for treatment after diabetes was established (DMB). 45 mg/kg STZ was given intravenously to the DM and DMB groups. One day later, the blood sugar levels of the rats were checked with a glucometer, and values above 300 mg/dl were accepted as diabetes. B. chrysogonum infusion prepared by weighing 3 grams every day for 5 weeks was given to the B and DMB groups by gavage. Their weights and blood sugar levels were measured and recorded every week. At the end of 5 weeks, it was observed that the blood sugar level of the DMB group decreased statistically significantly compared to the DM group. Then, the rats were sacrificed under deep anesthesia and their kidneys were removed. As a result of histopathological examination, glomerular basement membrane thickening and mesangial cell increase were observed in the kidneys of the DM group. Similar histopathological findings were observed in the kidneys of DMB group rats and K group kidneys. These results were supported by Periodic acid Schiff and reticular staining. As a result of this study, it was observed that B. chrysogonum lowered blood sugar level after diabetes and reduced kidney damage. The mechanism by which B. chrysogonum regulates blood sugar in diabetic rats and affects commonly occurring secondary injuries should be investigated in detail.