INVESTIGATION OF THE EFFECTS OF EXERCISE ON BLOOD GLUCOSE LEVELS IN RATS WITH EXPERIMENTAL T2DM MODEL
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https://doi.org/10.5281/zenodo.6976480%20Keywords:
Aerobic Exercise, Endurance Exercise, Type 2 Diabetes Mellitus, Rat, Resistance ExerciseAbstract
Diabetes mellitus is a metabolic syndrome with multiple etiologies involving insulin. T2DM accounts for 90-95% of diabetes mellitus. Obesity and physical inactivity play a critical role in the development of T2DM. Treatment and follow-up of this metabolic syndrome are tried to be controlled with diet, medication and lifestyle changes such as physical activity. Because diabetes mellitus is particularly associated with lifestyles, many studies have focused on the therapeutic effects of exercise on diabetes. The aim of this review is to examine the effects of exercise on blood glucose levels of rats with diabetes mellitus, which has become a global health problem. Although some previous studies have observed that running training does not reduce increased blood glucose levels in diabetic rats, other studies have proven that high blood glucose levels in diabetic rats are lowered by running training. Aerobic exercise applied to rats with T2DM as a treatment method; The addition of resistance and endurance exercises has also been shown to have a significant effect on lowering blood glucose levels and curing the disease. As a result, it can be said that when the intensity and duration of exercise are adjusted correctly, it reduces the progression of type 2 diabetes and increases the quality of life of individuals.
References
Abdolmaleki, F., & Heidarianpour, A. (2020). Endurance exercise training restores diabetes-induced alteration in circulating Glycosylphosphatidylinositol-specific phospholipase D levels in rats. Diabetology & metabolic syndrome, 12(1), 1-8.
Caliskan, H., Akat, F., Omercioglu, G., Bastug, G., Ficicilar, H., & Bastug, M. (2020). Aerobic exercise has an anxiolytic effect on streptozotocin induced diabetic rats. Acta Neurobiol Exp, 80, 245-255.
Fu, S., Meng, Y., Zhang, W., Wang, J., He, Y., Huang, L., ... & Du, H. (2019). Transcriptomic responses of skeletal muscle to acute exercise in diabetic goto-kakizaki rats. Frontiers in Physiology, 872.
Ghozhdi, H. D., Heidarianpour, A., Keshvari, M., & Tavassoli, H. (2021). Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats. Diabetology & Metabolic Syndrome, 13(1), 1-10.
Guariguata, L., Whiting, D. R., Hambleton, I., Beagley, J., Linnenkamp, U., & Shaw, J. E. (2014). Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes research and clinical practice, 103(2), 137-149.
Holzer, R., Bloch, W., & Brinkmann, C. (2022). Continuous Glucose Monitoring in Healthy Adults—Possible Applications in Health Care, Wellness, and Sports. Sensors, 22(5), 2030.
Hung, Y. H., Linden, M. A., Gordon, A., Scott Rector, R., & Buhman, K. K. (2015). Endurance exercise training programs intestinal lipid metabolism in a rat model of obesity and type 2 diabetes. Physiological reports, 3(1), e12232.
Kido, K., Ato, S., Yokokawa, T., Sato, K., & Fujita, S. (2018). Resistance training recovers attenuated APPL1 expression and improves insulin-induced Akt signal activation in skeletal muscle of type 2 diabetic rats. American Journal of Physiology-Endocrinology and Metabolism, 314(6), E564-E571.
Kim, S. S., Koo, J. H., Kwon, I. S., Oh, Y. S., Lee, S. J., Kim, E. J., ... & Cho, J. Y. (2011). Exercise training and selenium or a combined treatment ameliorates aberrant expression of glucose and lactate metabolic proteins in skeletal muscle in a rodent model of diabetes. Nutrition Research and Practice, 5(3), 205-213.
Lin, S., Jin, S., Zhou, F., Hu, Y., & Zhang, M. (2021). Effects of endurance exercise on serum inflammatory cytokine level and kidney structure in a rat diabetes model. Experimental and Therapeutic Medicine, 22(4), 1-9.
Lin, X., Yang, Y., Qu, J., & Wang, X. (2019). Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ. Nutrition & metabolism, 16(1), 1-13.
Macia, M., Pecchi, E., Desrois, M., Lan, C., Vilmen, C., Portha, B., ... & Giannesini, B. (2018). Exercise training impacts exercise tolerance and bioenergetics in gastrocnemius muscle of non-obese type-2 diabetic Goto-Kakizaki rat in vivo. Biochimie, 148, 36-45.
Moholdt, T., Parr, E. B., Devlin, B. L., Debik, J., Giskeødegård, G., & Hawley, J. A. (2021). The effect of morning vs evening exercise training on glycaemic control and serum metabolites in overweight/obese men: a randomised trial. Diabetologia, 64(9), 2061-2076.
Morifuji, T., Murakami, S., Fujita, N., Kondo, H., & Fujino, H. (2012). Exercise training prevents decrease in luminal capillary diameter of skeletal muscles in rats with type 2 diabetes. The Scientific World Journal, 2012.
Nakamoto, I., & Ishihara, A. (2020). Effects of voluntary running exercise on skeletal muscle properties in nonobese rats with type 2 diabetes. Physiological research, 69(1), 73-84.
Park, S. H., Yoon, J. H., Seo, D. Y., Kim, T. N., Ko, J. R., & Han, J. (2019). Resistance exercise training attenuates the loss of endogenous GLP-1 receptor in the hypothalamus of type 2 diabetic rats. International journal of environmental research and public health, 16(5), 830.
Qi, Z., He, J., Zhang, Y., Shao, Y., & Ding, S. (2011). Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. Free radical biology and medicine, 50(7), 794-800.
Shahwan, M., Alhumaydhi, F., Ashraf, G. M., Hasan, P. M., & Shamsi, A. (2022). Role of polyphenols in combating Type 2 Diabetes and insulin resistance. International Journal of Biological Macromolecules.
Shimomura, M., Horii, N., Fujie, S., Inoue, K., Hasegawa, N., Iemitsu, K., ... & Iemitsu, M. (2021). Decreased muscle‐derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes. Physiological Reports, 9(9), e14823.
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