Hypertension Treatment: The Role of Vitamin B12 and D Levels, Life Style, and Medication

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  • Meral EKİM
  • Hasan EKİM Bozok Üniversitesi




Hypertension, Mediterranean Diet, Vitamin B12, Vitamin D


Objective: Hypertension is an important public health problem worldwide, caused by the contribution of both genetic and environmental factors. Epidemiological studies have revealed that many environmental factors such as obesity, alcohol consumption, sodium intake and physical inactivity are associated with hypertension. Our aim is to evaluate the importance of vitamin B12 and vitamin D levels, lifestyle and nutrition in hypertensive patients and to review the effects of drugs used in the treatment of hypertension in the light of the literature.

Materials and Methods: Our study includes 40 patients followed up for hypertension between March 2021 and March 2023. In addition to routine laboratory tests, the levels of vitamin B12, vitamin D, folate and magnesium were measured in the patients. Salt-free Mediterranean diet was recommended to the patients. Our findings were expressed as mean ± standard deviation (SD) and number (percent). The t test was used for statistical analysis and a p value less than 0.05 was considered statistically significant.

Results: Twenty (50%) patients who participated in the study were female and 20 (50%) patients were male. The ages of the patients ranged from 36 to 77, and the mean age was 60.87±10.65 years. Vitamin B12 deficiency was detected in 6 (15%) patients. There was no significant difference between both genders in terms of mean vitamin B12 level (p>0.05). Vitamin D levels were below the normal level in all patients. The mean vitamin D level in female patients was significantly lower than in male patients (p<0.05). Atrial fibrillation (AF) was detected in 10 (25%) patients.

Conclusion: Vitamin D deficiency is common in patients with hypertension. Vitamin B12 deficiency should be taken into account in hypertension patients treated with metformin due to concomitant diabetes. Drug therapy in hypertension should be adjusted taking into account the accompanying diseases. Salt restriction, Mediterranean diet, outdoor activities in sunny weather and avoiding stress are the main lifestyle changes that should be applied in the treatment of hypertension. With appropriate lifestyle changes, the dose of antihypertensive drugs can also be reduced.


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How to Cite

EKİM , M., & EKİM , H. (2023). Hypertension Treatment: The Role of Vitamin B12 and D Levels, Life Style, and Medication. GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES, 8(4), 978–987. https://doi.org/10.5281/zenodo.10046284