VITAMIN B12 LEVELS IN THE ELDERLY DURING THE PANDEMIC PERIOD


Abstract views: 309 / PDF downloads: 153

Authors

DOI:

https://doi.org/10.5281/zenodo.6974070%20

Keywords:

Aging, COVID-19, Pandemic, Vitamin B12

Abstract

Vitamin B12, which plays an important role in many biological processes, has an important effect on various body functions and is an important micronutrient. People meet their vitamin B12 needs from animal products. The aim of this study is to investigate vitamin B12 deficiency, which is a risk factor for dementia and cardiovascular diseases, during the lockdown period applied to the elderly during the COVID-19 pandemic.

This study includes 39 patients over the age of 65 who applied to our hospital during the lockdown period due to the COVID-19 pandemic and whose vitamin B12 levels were measured. In this study, a vitamin B12 level below 200 pg/ml was accepted as vitamin B12 deficiency, and a folate level below 3 ng/ml was accepted as folate deficiency.

Of patients included in the study, 22 were males and 17 were females. Their ages ranged from 65 to 86 years, with a mean age of 73.9±5.9 years. Vitamin B12 levels of patients ranged from 83 pg/ml to 813 pg/ml, and the mean vitamin B12 level was 295.6±155.3. Vitamin B12 deficiency was detected in a total of 12 (30.76%) patients, 9 (40.9%) men and 3 (17.6%) women. The mean vitamin B12 level was significantly lower in men (p<0.05). Folate deficiency was present in 2 (5.12%) male patients with normal vitamin B12 levels.

Vitamin B12 deficiency is common in the elderly due to some drugs used due to the frequency of chronic diseases and malnutrition. Vitamin B12 deficiency is an important health problem in the elderly during the pandemic period. Avoiding vitamin B12 deficiency, which is a risk factor for dementia and cardiovascular diseases in the elderly, is important as it will prevent possible health problems. Unless there is an absorption disorder in the gastrointestinal tract, oral administration of vitamin B12 as in our series is also effective. Nutrition should also be regulated to keep biochemical parameters and serum vitamin B12 levels at normal concentrations.

References

Allen LH, Miller JW, de Groot L, et al. Biomarkers of nutrition for development (BOND): A review of vitamin B-12. J Nutr. 2018; 148(suppl_4): 1995H – 2027S.

Andres E, Affenberger S, Vinzio S, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med. 2005;118(10):1154–1159.

Atadağ Y, Aydın A, Köşker HD, Kaya D, Başak F. Vitamin B12 ve depresyon-aksiyete bozuklukları ilişkisi: Retrospektif kohort çalışma. Arch Clin Exp Med 2017;2(1):6-8.

Boran M, Boran Ö F, Yılmaz N, Canbakan B. Vitamin B12 Replasman Tedavisi; Oral? İntramüsküler?. Harran Üniversitesi Tıp Fakültesi Dergisi. 2020; 17(1): 19-23.

Brouwer-Brolsma EM, Dhonukshe-Rutten RA, van Wijngaarden JP, et al. Dietary sources of vitamin B-12 and their association with vitamin B-12 status markers in healthy older adults in the B-PROOF study. Nutrients. 2015;7(9):7781–7797.

Doets EL, Cavelaars AE, Dhonukshe-Rutten RA, et al. Explaining the variability in recommended intakes of folate, vitamin B12, iron and zinc for adults and elderly people. Public Health Nutr. 2012;15(5):906–915.

Doets EL, In 't Veld PH, Szczecińska A, et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 2013;62(4):311–322.

Emen B, Öztürk YK, Eren MA, Özdemir E, Öztürk F, Düzenli E, et al. B12 vitamin eksikliği bulunan hastalarda etiyolojik faktörler ile laboratuar verileri arasındaki ilişkinin geriye dönük değerlendirilmesi. Tepecik Eğit Hast Derg 2013; 23 (1).

Emerson Barbosa da Silva, Cintia Santos Bastos (2022) Effects of Vitamin B12 Deficiency on the Central Nervous System. Journal of Pathology Research Reviews and Reports. SRC/JPR-152. DOI: doi.org/10.47363/JPR/2022(4)140.

Fenech M. The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res 2001; 475: 57-67.

İpçioğlu OM, Özcan Ö, Gültepe M, Ateş A, Başoğlu C, Çakır E. Reduced urinary excretion of homocysteine could be the reason of elevated plasma homosistein in patients with psychiatric illnesses. Clin Biochem 2008; 10-11: 831-5.

Kara İH, Kandiş H, Bahçebaşı T, Köylü OK, Sayın S, Demirin H, et al. Check-up polikliniğine başvuran 50 yaş üzeri bireylerin folat, B12 vitamini düzeyleri ve anemi yönünden değerlendirilmesi. Turk J Biochem 2010;35(4):350-355.

Krasinski SD, Russell RM, Samloff IM, et al. Fundic atrophic gastritis in an elderly population. Effect on hemoglobin and several serum nutritional indicators. J Am Geriatr Soc. 1986;34(11):800–806.

Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatry Clin Neurosci 2012:24(1):5-15.

Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. NEngl J Med. 1988; 318(26): 1720 – 1728.

Malinow R, Andrew G. Homocysteine, diet, and cardiovascular disease. Circulation 1999; 99: 178-182

Özaydın N, Şensoy F, Özaydın N. Yaşlılarda besin ilaç etkileşimi. Sted 2016;25(3):125-130.

Özdem S, Gültekin M. Yaşlılarda serum B12 vitamini, folat ve plazma homosistein düzeyleri. Turkish Journal of Geriatrics. 2006; 9 (2): 59-64.

Patel, S.V., Makwana, A.B., Gandhi, A.U. et al. Factors associated with vitamin B12 deficiency in adults attending tertiary care Hospital in Vadodara: a case control study. Egypt J Intern Med 34, 11 (2022). https://doi.org/10.1186/s43162-022-00104-0.

Sobczyńska-Malefora A, Delvin E, McCaddon A, Ahmadi KR, Harrington DJ. Vitamin B12 status in health and disease: a critical review. Diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls. Crit Rev Clin Lab Sci. 2021;58(6):399-429. doi: 10.1080/10408363.2021.1885339.

Thamm M, Mensink GB, Thierfelder W. Folsäureversorgung von Frauen im gebärfähigen Alter [Folic acid intake of women in childbearing age]. Gesundheitswesen. 1999;61 Spec No:S207-12. German. PMID: 10726422.

Tucker KL, Mahnken B, Wilson PW, Jacques P, Selhub J. Folic acid fortification of the food supply. Potential benefits and risks for elderly population. JAMA 1996; 276: 1879-1885.

Tufan A. Yaşlılıkta Vitamin ve Eser Elementlerin Akılcı Kullanımı. Türkiye Klinikleri J Geriatr-Special Topics. 2016;2(2):77-80.

Sashindran VK, Aggarwal V, Khera A. Prevalence of Vitamin B12 deficiency in elderly population (>60 years) presenting with dementia to outpatient department. Med J Armed Forces India. 2022;78(1):94-98. doi: 10.1016/j.mjafi.2020.11.003.

Vogiatzoglou A, Smith AD, Nurk E, et al. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study. Psychosom Med. 2013;75(1):20–29.

Zhang Y, Hodgson NW, Trivedi MS, et al. Decreased brain levels of Vitamin B12 in aging, autism and schizophrenia. PLoS One. 2016;11(1):e0146797.

Published

2022-08-11

How to Cite

EKIM, M., & EKIM, H. (2022). VITAMIN B12 LEVELS IN THE ELDERLY DURING THE PANDEMIC PERIOD. GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES, 7(19), 35–41. https://doi.org/10.5281/zenodo.6974070

Issue

Section

Articles