Multiple Sclerosis in Childhood: A Single Center Experience

Abstract views: 112 / PDF downloads: 48


  • Olcay GÜNGÖR Pamukkale Üniversitesi Tıp Fakültesi



Childhood, Multiple Sclerosis, Treatment


In this study, the clinical and demographic characteristics of cases diagnosed with pediatric multiple sclerosis (pMS) in a single center between 2018 and 2023 were presented. This is a retrospective study covering fifteen cases aged between 6 and 18 years, who were admitted to the pediatric neurology clinic between January 2018 and 2023, were diagnosed with multiple sclerosis, and received treatment. Of the 15 cases diagnosed with multiple sclerosis and treatment initiated, 9 were girls (60%) and 6 were boys (40%). The girl/boy ratio was found to be 1.5. The average age of onset of symptoms in the cases was 12.6 years. The average age at diagnosis of the patients was 13.7 years and the median follow-up period was 3.17 years. A family history of multiple sclerosis was positive in one case (6.6%). According to the frequency of initial symptoms of our patients, 8 cases (57.8%) had motor symptoms, 5 cases (47.3%) had sensory symptoms, 4 cases (31.5%) had visual impairment, three cases (36.8%) had brainstem symptoms, and one case (10.5%) had visual impairment. ) cerebellar findings, first presented. MRI changes, periventricular lesions (14 patients, 93.3%), infratentorial changes (11 patients, 73.3%), juxtacortical and cortical changes (9 patients, 60%) and spinal cord involvement in 4 (26.6%) cases. detected.In our study, it was important that optic neuritis cases were slightly higher, it was quite rare under the age of 10, and EDSS scores were low with early treatment. However, multicenter, prospective studies involving larger study populations are needed to understand pMS.


Alroughani, R., & Boyko, A. J. B. n. (2018). Pediatric multiple sclerosis: a review. 18, 1-8.

Avila, M., Bansal, A., Culberson, J., & Peiris, A. N. J. E. n. (2018). The role of sex hormones in multiple sclerosis. 80(1-2), 93-99.

Banwell, B., Ghezzi, A., Bar-Or, A., Mikaeloff, Y., & Tardieu, M. J. T. L. N. (2007). Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions. 6(10), 887-902.

Banwell, B. L. J. M. S. J. (2008). Through the eyes of a child: research insights gained through the study of childhood multiple sclerosis. In (Vol. 14, pp. 4-5): Sage Publications Sage UK: London, England.

Boiko, A., Vorobeychik, G., Paty, D., Devonshire, V., & Sadovnick, D. J. N. (2002). Early onset multiple sclerosis: a longitudinal study. 59(7), 1006-1010.

Chitnis, T. J. N. (2013). Disease-modifying therapy of pediatric multiple sclerosis. 10(1), 89-96.

Deryck, O., Ketelaer, P., & Dubois, B. J. J. o. n. (2006). Clinical characteristics and long term prognosis in early onset multiple sclerosis. 253, 720-723.

Duquette, P., Murray, T. J., Pleines, J., Ebers, G. C., Sadovnick, D., Weldon, P., . . . Hader, W. J. T. J. o. p. (1987). Multiple sclerosis in childhood: clinical profile in 125 patients. 111(3), 359-363.

Filippi, M., Rocca, M. A., Ciccarelli, O., De Stefano, N., Evangelou, N., Kappos, L., . . . Frederiksen, J. L. J. T. L. N. (2016). MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. 15(3), 292-303.

Ghezzi, A., Deplano, V., Faroni, J., Grasso, M., Liguori, M., Marrosu, G., . . . Zaffaroni, M. J. M. S. J. (1997). Multiple sclerosis in childhood: clinical features of 149 cases. 3(1), 43-46.

Gorman, M. P., Healy, B. C., Polgar-Turcsanyi, M., & Chitnis, T. J. A. o. n. (2009). Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. 66(1), 54-59.

Hamdy, S. M., Abdel-Naseer, M., Shalaby, N. M., Elmazny, A., Girgis, M., Nada, M. A., . . . Treatment. (2018). Pediatric-onset multiple sclerosis in Egypt: a multi-center registry of 186 patients. 631-640.

Inaloo, S., Haghbin, S., Moradi, M., Dashti, H., & Safari, N. J. I. J. o. C. N. (2014). Acquired CNS demyelinating syndrome in children referred to ShirazPediatric Neurology Ward. 8(2), 18.

Jakimovski, D., Awan, S., Eckert, S. P., Farooq, O., & Weinstock-Guttman, B. J. C. d. (2022). Multiple sclerosis in children: differential diagnosis, prognosis, and disease-modifying treatment. 36, 45-59.

Kornbluh, A. B., & Kahn, I. (2023). Pediatric Multiple Sclerosis. Paper presented at the Seminars in Pediatric Neurology.

Krajnc, N., Oražem, J., Rener-Primec, Z., Kržan, M. J. M. s., & disorders, r. (2018). Multiple sclerosis in pediatric patients in Slovenia. 20, 194-198.

Krupp, L. B., Tardieu, M., Amato, M. P., Banwell, B., Chitnis, T., Dale, R. C., . . . Pohl, D. J. M. S. J. (2013). International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. 19(10), 1261-1267.

Langille, M. M., Islam, T., Burnett, M., & Amezcua, L. J. J. o. C. N. (2016). Clinical characteristics of pediatric-onset and adult-onset multiple sclerosis in Hispanic Americans. 31(8), 1068-1073.

Narula, S., Hopkins, S. E., & Banwell, B. J. C. t. o. i. n. (2015). Treatment of pediatric multiple sclerosis. 17, 1-12.

Nielsen, N. M., Westergaard, T., Rostgaard, K., Frisch, M., Hjalgrim, H., Wohlfahrt, J., . . . Melbye, M. J. A. j. o. e. (2005). Familial risk of multiple sclerosis: a nationwide cohort study. 162(8), 774-778.

Nikolić, B., Ivančević, N., Zaletel, I., Rovčanin, B., Samardžić, J., & Jančić, J. J. P. o. (2020). Characteristics of pediatric multiple sclerosis: A tertiary referral center study. 15(12), e0243031.

Ochi, H. J. C., & Neuroimmunology, E. (2017). Clinical features, diagnosis and therapeutic strategies in pediatric multiple sclerosis. 8, 33-39.

Otallah, S., Banwell, B. J. C. N., & Reports, N. (2018). Pediatric multiple sclerosis: an update. 18, 1-10.

Renoux, C., Vukusic, S., Mikaeloff, Y., Edan, G., Clanet, M., Dubois, B., . . . Pelletier, J. J. N. E. J. o. M. (2007). Natural history of multiple sclerosis with childhood onset. 356(25), 2603-2613.

Yamamoto, E., Ginsberg, M., Rensel, M., & Moodley, M. J. J. o. c. n. (2018). Pediatric-onset multiple sclerosis: a single center study. 33(1), 98-105.

Yılmaz, Ü., Anlar, B., Gücüyener, K., Yaramış, A., Cansu, A., Ünalp, A., . . . Tosun, A. J. e. j. o. p. n. (2017). Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. 21(6), 864-872.



How to Cite

GÜNGÖR , O. (2023). Multiple Sclerosis in Childhood: A Single Center Experience. GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES, 8(4), 1044–1048.