Evaluation of Iodine Deficiency Status of Children Diagnosed with Celiac Disease by Spot Urine Iodine/Creatinine Ratio
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Keywords:children, celiac disease, gluten, iodine, urine iodine/creatinine ratio
Aim: Celiac disease (CD) is caused by gluten sensitivity which leads to intestinal villi damage. This damage and strict diet can cause vitamin and mineral deficiencies; such as iodine. The aim of this study is to assess the iodine deficiency status in children diagnosed with CD by measuring spot urine iodine/creatinine levels.
Material-Method: Totally 66 (42 girls, 24 boys) children with CD who were followed up in Pediatric Gastroenterology Outpatient Clinic between 18.09.2017-01.12.2022 were included in this retrospective study. Anthropometric and laboratory data were obtained from patient files. All the clinical, biochemical values and spot urine iodine/creatinine ratio were analyzed.
Results: The mean age of the patients was 9.73 ± 3.84 years, and the mean age at diagnosis was 6.57 ± 3.86 years, disease duration was 3.16 ± 2.34 years. The mean spot urinary iodine/creatinine ratio of the participants was 146.20 ± 113.59 μg/g. According to multivariate analysis results, a significant negative correlation was determined between mean patient age and urinary iodine/creatinine ratio (p = 0.009). No significant correlation between other parameters were found (p > 0.05). The patients were divided into two groups: Group 1; as the group with adequate dietary compliance, Group 2; insufficient dietary compliance. The mean spot urinary iodine/creatinine ratio of Group 1 was higher than Group 2, but this difference was not statistically significant (152.26 ± 120.51 μg/g vs. 134.65 ± 100.68 μg/g; p=0.560). The other parameters were also statistically insignificant (p>0.05).
Conclusion: This is the first study in the literature to use the spot urinary iodine/creatinine ratio in the evaluation of iodine deficiency in children and adolescents with CD. The mean spot urinary iodine/creatinine ratio of celiac patients in our study was similar in healthy populations of the same age group, regardless of dietary adherence. In this area; prospective, randomized controlled studies with more subjects are needed.
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