Efficacy of Trastuzumab Emtansine Therapy in Sequantial Treatment in Patients with HER2-Positive Metastatic Breast Cancer


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Authors

  • Serdar ATA adana şehir hastanesi tıbbi onkoloji
  • Burcu ARSLAN BENLİ
  • Oğuzhan KESEN
  • Ahmet Ziya BAYHAN
  • Hakan DEMİR
  • Ömer DEMİROĞLU
  • Ali Alper SOLMAZ
  • Timuçin ÇİL
  • Berna BOZKURT DUMAN

DOI:

https://doi.org/10.5281/zenodo.7931256

Keywords:

Breast cancer, HER-2, Pertuzumab, Trastuzumab emtansine

Abstract

Aim: The aim of this study was to evaluate the efficacy of Lapatinib, trastuzumab emtansine (T-DM1) treatment after pertuzumab in patients with HER2-positive metastatic breast cancer.

Materials and Methods: The study included HER2-positive breast cancer patients who were followed up and treated in Adana City Training and Research Hospital. Totally 1840 patients with a diagnosis of breast cancer in the hospital management system were evaluated, 670 patients who were determined to be metastatic were evaluated for eligibility. Thirty-one patients who received pertuzumab before T-DM1 treatment, while 34 patients who received T-DM1 before pertuzumab were included.

Results: Of the 65 female patients included in the study, 59 had ductal adenocarcinoma (90.8%) and 6 had lobular adenocarcinoma (9.2%). Seventeen patients (26.2%) had bone metastases, 20 patients (30.7%) had visceral metastases, and 28 patients (43.1%) had bone and visceral metastases together. Overall survival (OS) was 23.8±3 months in those who did not receive pertuzumab before T-DM1 in the metastatic setting, while it was similar in those who received pertuzumab with 22.4±2.9 months (p=0.969). Progression-free survival (PFS) was 9.1±1.3 months in those who did not receive pertuzumab before T-DM1 in the metastatic setting, while it was significantly lower in patients who received pertuzumab with 4.9±0.8 months (p=0.005). The comparison of initiation of T-DM1 after pertuzumab as second-line therapy in the metastatic setting and its use in later therapeutic lines revealed no difference in PFS and OS (p=0.628 and p=0.706, respectively).

Conclusion: Pertuzumab should be preferred primarily because it is more effective in metastatic HER2-positive breast cancer. Despite the significant decrease in PFS of patients using T-DM1 after pertuzumab, there was no decrease in OS; therefore the earlier T-DM1 therapy is initiated following pertuzumab, the more effective it is.

Author Biographies

Burcu ARSLAN BENLİ

Translator      

 

 

Oğuzhan KESEN

Translator      

 

 

Ahmet Ziya BAYHAN

Translator      

 

Translator      

 

 

Hakan DEMİR

Translator      

 

 

Ömer DEMİROĞLU

Translator      

 

 

Ali Alper SOLMAZ

Translator      

 

 

Timuçin ÇİL

Translator      

 

 

Berna BOZKURT DUMAN

Translator      

 

 

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Published

2023-05-13

How to Cite

ATA, S., ARSLAN BENLİ , B., KESEN , O., BAYHAN , A. Z., DEMİR , H., DEMİROĞLU , Ömer, SOLMAZ , A. A., ÇİL , T., & BOZKURT DUMAN , B. (2023). Efficacy of Trastuzumab Emtansine Therapy in Sequantial Treatment in Patients with HER2-Positive Metastatic Breast Cancer. GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES, 8(2), 431–436. https://doi.org/10.5281/zenodo.7931256

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