Long Term Follow up COVID-19 Patients
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https://doi.org/10.5281/zenodo.10612448Keywords:
COVID-19, post-COVID, radiology, quality of life questionnairesAbstract
This study aimed to investigate the presence of symptoms that persist after discharge in patients with COVID-19 and their effects on quality of life.
Ninety COVID-19 patients who were hospitalized between January and April 2021 were included in the study. Demographic data, comorbidities, imaging and laboratory findings of the patients were recorded. During the follow-up visits, the patients' symptoms were questioned, quality of life questionnaires were filled out, laboratory findings were recorded, and radiological examinations were performed.
It was determined that 28 of the patients did not require O2 (Group 1), 46 required O2 (Group 2), and 16 required IMV-NIMV (Group 3). There was no difference between the 3 groups in terms of gender. It was determined that the average age and comorbidity rate of Group 3 was higher than Group 1 and Group 2. Among the thorax CT findings, ground glass opacity and consolidation were the most common findings. Since all patients in Group 3 died during hospitalization, they could not be included in post-COVID evaluation. In the 3rd month post-COVID, the reticular pattern and ground glass ratio were determined to be higher in Group 2 than in Group 1. In the 6th month post-COVID, only 2 patients in Group 2 had pathological findings on Thorax CT. It was determined that 88.6% of all patients had symptoms in the 3rd post-COVID month, and the most common symptoms were fatigue and myalgia. It was determined that none of the cases had symptoms in the 6th month post-COVID. In the surveys evaluating the quality of life conducted in the 3rd and 6th months of post-COVID, it was determined that there was no difference between the groups, and the majority of patients in both groups returned to their pre-COVID health status.
In conclusion, patients diagnosed with COVID-19 should be followed after discharge, because symptoms and signs may persist for up to 6 months. It can be thought that the risk of post-COVID sequelae is low in patients who do not need intensive care during hospitalization.
References
Abdullah M, Chai P, Chong M, Tohit ERM, Ramasamy R, Pei CP, Vidyadaran S. Gender effect on in vitro lymphocyte subset levels of healthy individuals. Cell Immunol 2012; 272(2): 214–219.
Admon AJ, Iwashyna TJ, Kamphuis LA, Gundel SJ, Sahetya SK, Peltan ID, et al. Assessment of symptom, disability, and financial trajectories in patients hospitalized for COVID-19 at 6 months. JAMA Netw Open 2023; 6: e2255795.
Alsofayan YM, Althunayyan SM, Khan AA, Hakawi AM, Assiri AM. Clinical characteristics of COVID-19 in Saudi Arabia: A national retrospective study. J Infect Public Health 2020; 13(7): 920–925.
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020; 11: 995–998.
Bao C, Liu X, Zhang H, Li Y, Liu J. Coronavirus Disease 2019 (COVID-19) CT Findings: A systematic review and meta-analysis. J Am Coll Radiol 2020; 17(6): 701–709.
Boscolo-Rizzo P, Guida F, Polesel J, Marcuzzo AV, Capriotti V, D'Alessandro A, et al. Sequelae in adults at 12 months after mild-to-moderate coronavirus disease 2019 (COVID-19). Int Forum Allergy Rhinol 2021; 11: 1685–1688.
Boscolo-Rizzo P, Guida F, Polesel J, Marcuzzo AV, Antonucci P, Capriotti V, et al. Self-reported smell and taste recovery in coronavirus disease 2019 patients: A one-year prospective study. Eur Arch Otorhinolaryngol 2022; 279(1): 515-520.
Cai H. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir Med 2020; 8(4): e20.
Carfì A, Bernabei R, Landi F. Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19. JAMA 2020; 324(6): 603-605.
Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int 2020; 97(5): 829–838.
Children and COVID-19: State-Level Data Report. American Academy of Pediatrics. [2021-09-07]
Daynes E, Gerlis C, Briggs-Price S, Jones P, Singh SJ. COPD assessment test for the evaluation of COVID-19 symptoms. Thorax 2021; 76(2): 185-187.
Dolan P, Gudex C, Kind P, Williams A. The time trade-off method: Results from a general population study. Health Econ 1996; 5(2): 141-154.
Ettman CK, Abdalla SM, Cohen GH, Sampson L, Vivier PM, Galea S. Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic. JAMA Netw Open 2020; 3(9): e2019686-e2019686.
Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, et al. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSPCOVID): a UK multicentre, prospective cohort study. Lancet Respir Med 2021; 9: 1275–1287.
Fan E, Dowdy DW, Colantuoni E, Mendez-Tellez PA, Sevransky JE, Shanholtz C,et al. Physical complications in acute lung injury survivors: A two-year longitudinal prospective study. Crit Care Med 2014; 42(4): 849-859.
Fernández-de-Las-Peñas C, Guijarro C, Plaza-Canteli S, Hernández-Barrera V, Torres-Macho J. Prevalence of post-COVID-19 cough one year after SARS-CoV-2 Infection: a multicenter study. Lung 2021; 199(3): 249-253.
Gebhard C, Regitz-Zagrosek V, Neuhauser HK, Morgan R, Klein SL. Impact of sex and gender on COVID-19 outcomes in Europe. Biol Sex Differ 2020; 11(1): 29.
Gemelli Against COVID-19 Post-Acute Care Study Group. Post-COVID-19 global health strategies: the need for an interdisciplinary approach. Aging Clin Exp Res 2020; 32(8): 1613-1620.
Groff D, Sun A, Ssentongo AE, Ba DM, Parsons N, Poudel GR, et al. Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection. A systematic review. JAMA Network Open 2021; 4(10): e2128568.
Guler SA, Ebner L, Aubry-Beigelman C, Bridevaux PO, Brutsche M, Clarenbach C, et al. Pulmonary function and radiological features 4 months after COVID-19: First results from the na-tional prospective observational Swiss COVID-19 lung study. Eur Respir J 2021; 57(4): 2003690
Han R, Huang L, Jiang H, Dong J, Peng H, Zhang D. Early clinical and CT manifestations of Coronavirus Disease 2019 (COVID-19) pneumonia. AJR Am J Roentgenol 2020; 215(2): 338–343.
Hewagama A, Patel D, Yarlagadda S, Strickland FM, Richardson BC. Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis. Genes Immun 2009; 10(5): 509–516.
Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021; 397(10270): 220-232.
Huang I, Pranata R, Lim M.A, Oehadian A, Alisjahbana B. C-reactive protein, procalcitonin, D-Dimer, and ferritin in severe coronavirus disease-2019: A meta-analysis. Ther Adv Respir Dis 2020; 14: 1–14.
Forte G, Favieri F, Tambelli R, Casagrande M. COVID-19 pandemic in the Italian population: validation of a post- traumatic stress disorder questionnaire and prevalence of PTSD symptomatology. Int J Environ Res Public Health 2020; 17(11): 4151.
Jin J, Bai P, He W, Wu F, Liu X, Han D, et al. Gender differences in patients with COVID-19: Focus on severity and mortality. Front Public Health 2020; 8: 152.
Jordan RE, Adab P, Cheng KK. Covid-19: Risk factors for severe disease and death. BMJ 2020; 368: m1198. doi: 10.1136/bmj.m1198.
Liu C, Ye L, Xia R, Zheng X, Yuan C, Wang Z, et al. Chest computed tomography and clinical follow-up of discharged patients with COVID-19 in Wenzhou City, Zhejiang, China. Ann Am Thorac Soc 2020; 17(10): 1231-1237.
Liu J, Deswal A, Khalid U. COVID-19 myocarditis and long-term heart failure sequelae. Curr Opin Cardiol 2021 ;36(2): 234-240
Liu Y, Mao B, Liang S, Yang J, Lu H, Chai Y, et al. Shanghai Clinical Treatment Experts Group for COVID-19 Association between age and clinical characteristics and outcomes of COVID-19. Eur Respir J 2020; 55(5): 2001112.
Logue JK, Franko NM, McCulloch DJ, McDonald D, Magedson A, Wolf CR, Chu HY. Sequelae in adults at 6 months after COVID-19 infection. JAMA Netw Open 2021; 4(2): e210830.
Lorent N, Weygaerde YV, Claeys E, Fajardo IGC, De Vos N, Wever WD, et al. Prospective longitudinal evaluation of hospitalised COVID-19 survivors 3 and 12 months after discharge. ERJ Open Res 2022; 8: 00004-2022.
Mandal S, Barnett J, Brill SE, Brown JS, Denneny EK, Hare SS, et al. Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19. Thorax 2021; 76(4): 396-398.
Nayagam JS, Jeyaraj R, Mitchell T, Walder DP, Al-Agil M, Shek A, et al. Patterns and prediction of liver injury with persistent cholestasis in survivors of severe SARS-CoV-2 infection. J Infect 2021; 82: 11–13.
Ngai JC, Ko FW, Ng SS, To KW, Tong M, Hui DS. The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status. Respirology 2010; 15: 543–550.
O'Driscoll M, Ribeiro Dos Santos G, Wang L, Cummings DAT, Azman AS, Paireau J, et al. Age-specific mortality and immunity patterns of SARS-CoV-2. Nature 2021; 590(7844): 140–145.
O'Mahoney LL, Routen A, Gillies C, Ekezie W, Welford A, Zhang A, et al. The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: A systematic review and meta-analysis. EClinicalMedicine 2022; 55: 101762.
Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, et al; GCCR Group Author. More than smell-COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chem Senses 2020; 45(7): 609-622.
Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun 2020; 11(1): 6317.
Pormohammad A, Ghorbani S, Baradaran B, Khatami A, J Turner R, Mansournia MA, et al. Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis. Microb Pathog 2020; 147: 104390.
Qaisieh R, Al-Tamimi M, El-Hammuri N, Shalabi M, Kilani MM, Taha H, et al. Clinical, laboratory, and imaging features of COVID-19 in a cohort of patients: Cross-sectional comparative study. JMIR Public Health Surveill 2021; 7(9): e28005.
Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al, Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19) Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis 2020; 34: 101623.
Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID-19): A systematic review of imaging findings in 919 patients. AJR Am J Roentgenol 2020; 215(1): 87–93.
Shah AS, Wong AW, Hague CJ, Murphy DT, Johnston JC, Ryerson CJ, Carlsten C. A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations. Thorax 2021; 76(4): 402-404.
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. Attributes and predictors of long COVID. Nat Med 2021; 27(4): 626-631.
Sun P, Qie S, Liu Z, Ren J, Li K, Xi J. Clinical characteristics of 50466 hospitalized patients with 2019-nCoV infection. J Med Virol 2020; 92(6): 612-617.
Sümer Ş, Ural O, Aktuğ N, Çiftçi Ş, Türkseven B, Kılınçer A, et al. Selçuk Üniversitesi Tıp Fakültesi Hastanesi’nde izlenen COVID-19 olgularının klinik ve laboratuvar özellikleri. Klimik Dergisi 2020; 33(2): 122-127.
The EuroQoL Group. EuroQoL-a new facility for the measurement of health- related quality of life. Health Policy 1990; 16: 199-208.
Tran VT, Porcher R, Pane I, Ravaud P. Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort. Nat Commun 2022; 13: 1812.
Townsend L, Dowds J, O’Brien K, Sheill G, Dyer AH, O’Kelly B, et al. Persistent poor health post-COVID-19 is not associated with respiratory complications or initial disease severity. Ann Am Thorac Soc 2021; 18(6): 997-1003.
Vijayakumar B, Tonkin J, Devaraj A, Philip KEJ, Orton CM, Desai SR, Shah PL. CT lung abnormalities after COVID-19 at 3 months and 1 year after hospital discharge. Radiology 2022; 303(2): 444-454.
Wagner J, DuPont A, Larson S, Cash B, Farooq A. Absolute lymphocyte count is a prognostic marker in Covid-19: A retrospective cohort review. Int J Lab Hematol 2020; 42(6): 761–765.
Wang F, Kream RM, Stefano GB. Long-term respiratory and neurological sequelae of COVID-19. Med Sci Monit 2020; 26: e928996.
Wang L, Wang Y, Ye D, Liu Q. Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence. Int J Antimicrob Agents 2020; 55(6): 105948.
World Health Organisation. Post COVID-19 condition (long COVID). Dec 7, 2022. https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition (accessed May 5, 2023).
WHO announces COVID-19 outbreak a pandemic. https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces covid-19-outbreak-a-pandemic. Published December 3, 2020. Accessed May 22, 2021.
WHO. WHO Coronavirus (COVID-19) Dashboard. 2023. https://covid19.who.int (accessed July 1, 2023).
Wong HYF, Lam HYS, Fong AH, Leung ST, Chin TW, Lo CSY, et al. Frequency and distribution of chest radiographic findings in patients positive for COVID-19. Radiology 2022; 296(2): 72–78.
Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020; 180(7): 934-943.
Wu JT, Leung K, Bushman M, Kishore N, Niehus R, de Salazar PM, Cowling BJ, et al. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. Nat Med 2020; 26(4): 506-510.
Wulf Hanson S, Abbafati C, Aerts JG, Al-Aly Z, Ashbaugh C, Ballouz T, et al. Estimated global proportions of individuals with persistent fatigue, cognitive, and respiratory symptom clusters following symptomatic COVID-19 in 2020 and 2021. JAMA 2022; 328: 1604–1615.
Wu X, Dong D, Ma D. Thin-section computed tomography manifestations during convalescence and long-term follow-up of patients with severe acute respiratory syndrome (SARS). Med Sci Monit 2016; 22: 2793–2799.
Wu X, Liu X, Zhou Y, Yu H, Li R, Zhan Q, et al. 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: A prospective study. Lancet Respir Med 2021; 9(7): 747-754.
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13): 1239-1242.
Wynberg E, van Willigen HDG, Dijkstra M, Boyd A, Kootstra NA, van den Aardweg JG, et al. Evolution of COVID-19 symptoms during the first 12 months after illness onset. Clin Infect Dis 2022; 75(1): 482-490.
Zeng F, Huang Y, Guo Y, Yin M, Chen X, Xiao L, Deng G. Association of inflammatory markers with the severity of COVID-19: A meta-analysis. Int J Infect Dis 2020; 96: 467–474.
Zenga F, Huang Y, Guo Y, Yin M, Chen X, Xiao L, Deng G. Association of inflammatory markers with the severity of COVID-19: A meta-analysis. Int J Infect Dis 2020; 96: 467-474.
Zhang X, Wang F, Shen Y, Zhang X, Cen Y, Wang B, et al. Symptoms and health outcomes among survivors of COVID-19 infection 1 year after discharge from hospitals in Wuhan, China. JAMA Netw Open 2021; 4(9): e2127403.
Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Deng Y, et al. Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis. Int J Infect Dis 2020; 96: 131–135.
Zhao YM, Shang YM, Song WB, Li QQ, Xie H, Xu QF, et al. Follow-up study of the pulmonary function and related physiological characteristics of covid-19 survivors three months after recovery. EClinicalMedicine 2020; 25: 100463.
Zhou F, Tao M, Shang L, Liu Y, Pan G, Jin Y, et al. Assessment of sequelae of COVID-19 nearly 1 year after diagnosis. Front Med (Lausanne) 2021; 8: 717194. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020; 395: 1054-1062.
Zhou Y, Fu B, Zheng X, Wang D, Zhao C. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe Covid-19 patients. Natl Sci Rev 2020; 7(6): 998-1002.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382: 727–733.
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