Prognostic Value of NT-proBNP and Some Coagulation Markers in Severe COVID-19 Patients
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https://doi.org/10.5281/zenodo.7393022Keywords:
COVID-19, Coagulation Markers, NT-proBNP, Cardiac dysfunction, D-dimer, Fibrinogen, INRAbstract
Objective: The aim of our study is to examine the effect of N-terminal fragment of the pro-brain natriuretic peptide (NT-proBNP) and some coagulation markers (D-dimer, fibrinogen and International Normalized Ratio (INR)) on mortality in COVID-19 patients over the age of 18.
Materials and Methods: In the study, the relationship between D-dimer, fibrinogen, and INR with NT-proBNP in 1614 patients diagnosed with COVID-19 was evaluated retrospectively, considering the survival status of the patients. The patients were divided into two groups as 18-65 years old and over 65 years old.
Results: Among 1614 patients, 213 NT-proBNP and D-dimer levels were measured; NT-proBNP and fibrinogen levels were measured 161; there were 233 patients whose NT-proBNP and INR levels were measured. NT-proBNP levels were significantly higher in all patients who died. High D-dimer level in 96.7% of deaths in NT-proBNP~D-dimer group, high fibrinogen level in 80.2% of deaths in NT-proBNP~fibrinogen group; high INR levels were detected in 82.8% of the deaths in the NT-proBNP~INR group.
Conclusion: The results of our study showed that high NT-proBNP and high coagulation marker levels (D-dimer, fibrinogen, INR) may have an effect on mortality in patients who died due to COVID-19.
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