Prognostic Value of NT-proBNP and Some Coagulation Markers in Severe COVID-19 Patients
Abstract views: 129
/ 
PDF downloads: 66
DOI:
https://doi.org/10.5281/zenodo.7393022Keywords:
COVID-19, Coagulation Markers, NT-proBNP, Cardiac dysfunction, D-dimer, Fibrinogen, INRAbstract
Objective: The aim of our study is to examine the effect of N-terminal fragment of the pro-brain natriuretic peptide (NT-proBNP) and some coagulation markers (D-dimer, fibrinogen and International Normalized Ratio (INR)) on mortality in COVID-19 patients over the age of 18.
Materials and Methods: In the study, the relationship between D-dimer, fibrinogen, and INR with NT-proBNP in 1614 patients diagnosed with COVID-19 was evaluated retrospectively, considering the survival status of the patients. The patients were divided into two groups as 18-65 years old and over 65 years old.
Results: Among 1614 patients, 213 NT-proBNP and D-dimer levels were measured; NT-proBNP and fibrinogen levels were measured 161; there were 233 patients whose NT-proBNP and INR levels were measured. NT-proBNP levels were significantly higher in all patients who died. High D-dimer level in 96.7% of deaths in NT-proBNP~D-dimer group, high fibrinogen level in 80.2% of deaths in NT-proBNP~fibrinogen group; high INR levels were detected in 82.8% of the deaths in the NT-proBNP~INR group.
Conclusion: The results of our study showed that high NT-proBNP and high coagulation marker levels (D-dimer, fibrinogen, INR) may have an effect on mortality in patients who died due to COVID-19.
References
Abdeen, Y., Kaako, A., Alnabulsi, M., Okeh, A., Meng, W., & Miller, R. (2021). The prognostic effect of brain natriuretic peptide levels on outcomes of hospitalized patients with COVID-19. Avicenna Journal of Medicine, 11(1), 20–26. https://doi.org/10.4103/ajm.ajm_169_20
Colling, M. E., & Kanthi, Y. (2020). COVID–19-associated coagulopathy: An exploration of mechanisms. Vascular Medicine (United Kingdom), 25(5), 471–478. https://doi.org/10.1177/1358863X20932640
Dyah, C., Wungu, K., Khaerunnisa, S., Arum, E., & Putri, C. (2021). Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19. International Journal of Infectious Diseases, 105, 551–559. https://doi.org/https://doi.org/10.1016/j.ijid.2021.03.008
Gao, L., Jiang, D., Wen, X. S., Cheng, X. C., Sun, M., He, B., …, Zhang, D. Y. (2020). Prognostic value of NT-proBNP in patients with severe COVID-19. Respiratory Research, 21(1), 1–7. https://doi.org/10.1186/s12931-020-01352-w
Gerotziafas, G. T., Catalano, M., Colgan, M. P., Pecsvarady, Z., Wautrecht, J. C., Fazeli, B., … , Roldan, V. (2020). Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine. Thrombosis and Haemostasis, 120(12), 1597–1628. https://doi.org/10.1055/s-0040-1715798
Han, H., Xie, L., Liu, R., Yang, J., Liu, F., Wu, K., ..., Zhu, C. (2020). Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China. Journal of Medical Virology, 92(7), 819–823. https://doi.org/10.1002/jmv.25809
He, X., Wang, L., Wang, H., Xie, Y., Yu, Y., Sun, J., …, Zeng, H. (2020). Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19. Scientific Reports, 10(1), 1–9. https://doi.org/10.1038/s41598-020-77172-1
Inciardi, R. M., Adamo, M., Lupi, L., Cani, D. S., Di Pasquale, M., Tomasoni, D., … ,Metra, M. (2020). Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. European Heart Journal, 41(19), 1821–1829. https://doi.org/10.1093/eurheartj/ehaa388
Mahajan, K., Negi, P. C., Ganju, N., & Asotra, S. (2020). Cardiac biomarker-based risk stratification algorithm in patients with severe COVID-19. January.
Qin, J. J., Cheng, X., Zhou, F., Lei, F., Akolkar, G., Cai, J., …, Li, H. (2020). Redefining cardiac biomarkers in predicting mortality of inpatients with COVID-19. Hypertension, 1104–1112. https://doi.org/10.1161/HYPERTENSIONAHA.120.15528
Tang, N., Li, D., Wang, X., & Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis, 18(4), 844–847. https://doi.org/10.1111/jth.14768
Tuo, H., Li, W., Tang, L., He, B., Yao, B., Mao, P., & Tang, Q. (2021). Cardiac biomarker abnormalities are closely related to prognosis in patients with COVID-19. International Heart Journal, 62(1), 148–152. https://doi.org/10.1536/ihj.20-180
Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., … , Song, Y. (2020). Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Internal Medicine, 180(7), 934–943. https://doi.org/10.1001/jamainternmed.2020.0994
Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., …, Dong, K. (2020). Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. BMJ Open Diabetes Research and Care, 8(1), 1–9. https://doi.org/10.1136/bmjdrc-2020-001343
Yang, C., Liu, F., Liu, W., Cao, G., Liu, J., Huang, S., …, Xiong, B. (2021). Myocardial injury and risk factors for mortality in patients with COVID-19 pneumonia. International Journal of Cardiology, 326, 230–236. https://doi.org/10.1016/j.ijcard.2020.09.048
Zhai, Z., Li, C., Chen, Y., Gerotziafas, G., Zhang, Z., Wan, J., …, Wang, C. (2020). Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines. Thrombosis and Haemostasis, 120(6), 937–948. https://doi.org/10.1055/s-0040-1710019
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., …, Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, 395(10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The journal is licensed under a 