Şiddetli COVID-19 Hastalarında NT-proBNP ve Bazı Koagülasyon Belirteçlerinin Prognostik Değeri
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DOI:
https://doi.org/10.5281/zenodo.7393022Anahtar Kelimeler:
COVİD-19, koagülasyon belirteçleri, NT-proBNP, kardiyak bozukluk, D-dimer, fibrinojen, INRÖzet
Amaç: Çalışmamızın amacı, 18 yaş üstü COVID-19 hastalarında NT-proBNP ile bazı pıhtılaşma belirteçlerinin (D-dimer, fibrinojen ve INR) mortalite üzerine etkisini incelemektir.
Gereç ve Yöntem: Çalışmada COVID-19 tanısı alan 1614 hastada D-dimer, fibrinogen ve INR ile NT-proBNP arasındaki ilişki, hastaların hayatta kalıp kalmama durumları göz önünde bulundurularak retrospektif olarak değerlendirildi. Hastalar 18-65 yaş ve 65 yaş üstü olmak üzere iki gruba ayrıldı.
Bulgular: 1614 hasta arasında NT-proBNP ve D-dimer düzeyleri ölçülmüş 213; NT-proBNP ve fibrinojen düzeyleri ölçülmüş 161; NT-proBNP ve INR düzeyleri ölçülmüş 233 hasta vardı. NT-proBNP seviyeleri, ölen tüm hastalarda anlamlı olarak yüksekti. NT-proBNP~D-dimer grubunda ölenlerin % 96,7'sinde yüksek D-dimer düzeyi, NT-proBNP~Fibrinojen grubunda ölenlerin %80,2'sinde yüksek fibrinojen düzeyi; NT-proBNP~INR grubunda ölenlerin %82.8'inde yüksek INR seviyeleri tespit edildi.
Sonuç: Çalışmamızın sonuçları, COVID-19 nedeniyle ölen hastalarda yüksek NT-proBNP ile yüksek pıhtılaşma belirteç düzeylerinin (D-dimer, fibrinojen, INR) mortalite üzerine etkisi olabileceğini gösterdi.
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