The Relationship Of Arterial Stiffness And Aortic Augmentation Index With Coronary Artery Disease In Patients With Stable Angina Pectoris

Abstract

Objective : Many studies have indicated arterial stiffness as an independent predictor of hypertension, stroke, cardiovascular events, and mortality. However, the relationship between the severity of coronary artery disease(CAD) and arterial stiffness is still unclear. In this study, it was aimed to examine the relationship between augmentation index which is a marker of arterial stiffness with CAD and its prevalence.

Methods: A total of 80 patients (22 female, mean age 59±8) who were scheduled for coronary angiography with a preliminary diagnosis of coronary artery disease by evaluating their symptoms and findings and coronary risk profiles were included. The other group have 20 healthy patients without any chronic disease history. The augmentation index (AIX), which is an indicator of arterial stiffness, was measured in all cases with the BP+ Central Blood Pressure CardioScope II device in all groups. Gensini scores of the patients who underwent elective coronary angiography were calculated.

Results: AIX was found to be 131% (79-198mmHg) in patient group and 72.5% (69-96mmHg) in control group (p<0.001). A positive correlation was observed between AIX and Gensini score, LDL-cholesterol, body mass index and HbA1c in the patient group. In the ROC analysis, the area under the curve (AUC) for AIX was calculated as 0.701 (P<0.001). While AIX was 121% above normal, it predicted coronary artery disease with 94.8% sensitivity and 80.9% specificity.

Conclusion: In our study, a relationship was found between coronary artery disease severity and arterial stiffness. Augmentation index can be used effectively with low cost in predicting coronary artery disease.