INVESTIGATION OF LEVELS OF SERUM PENTRAXIN-3 AND CRP IN SICKLE CELL ANEMIA

Abstract

ABSTRACT Sickle cell anemia (SCA) is one of the hemoglobinopathies with a high prevalence both in the world and in our country, so its importance is increasing. Infections are among the most common causes of mortality in SCA patients. Based on this, in this study, it was aimed to investigate the levels of Pentraxin-3 and C-reactive protein, which are acute phase reactants that increase in inflammatory and ischemia conditions, in patients with SCA. A total of 89 individuals, including 44 patients (23-40 years old) and 45 healthy controls (21-48 years old) diagnosed with SAD, were included in the study. CRP levels were studied by immunoturbidimetric method in Cobas Integra 800 device, and PTX3 levels were measured by ELISA method. CRP and PTX3 levels were found to be increased in the patient group with SCA compared to the healthy group (p <0.001). However, when evaluated in terms of PTX3 and CRP levels, it was found that there was no significant correlation between the patient with SCA and healthy control groups (r = -0.188, p = 0.22; r = -0.117, p = 0.445; respectively). As a result of the data obtained, we think that PTX3 and CRP with increased levels in many inflammatory diseases can be useful in the follow-up of SCA.