The Effect of Vaccination Status on COVID-19 Infection Symptoms during Pregnancy and Subsequent Attitudes towards Medication Use: A Case-Control Study
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https://doi.org/10.5281/zenodo.18178153Keywords:
COVID-19, Drug use, Pregnancy Symptoms, VaccineAbstract
Objective: The aim of this study was to determine the effect of COVID-19 vaccination on symptoms of COVID-19 during pregnancy and subsequent medication use.
Materials and Methods: In the study, pregnant women who were admitted to the COVID-19 Septic Service of a public hospital, received COVID-19 vaccine and were diagnosed with COVID-19 constituted the case group. Pregnant women in the case group were matched for age (±1 year) and gestational week (±1 week) with pregnant women who did not receive COVID-19 vaccination and were diagnosed with COVID-19 at the appropriate service to form a control group. The study was completed with a total of 116 pregnant women, 65 case and 51 control. The Participant Information Form and Pregnancy Symptom Inventory were used to collect data.
Results: In the study, there was a significant correlation between COVID-19 vaccination status and COVID-19 symptoms of fever, shortness of breath, fatigue and headache (p<0.005). Pregnant women who received COVID-19 vaccine were found to use vitamin and mineral supplements at a significant level (OR=5.71, p=0.039).
Conclusion: Pregnant women receiving COVID-19 vaccine had fewer COVID-19 symptoms and more vitamin and mineral supplements.
References
Antonelli, M., Penfold, R. S., Merino, J., Sudre, C. H., Molteni, E., Berry, S., … Steves, C. J. (2022). Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: A prospective, community-based, nested, case-control study. The Lancet Infectious Diseases, 22(1), 43–55.
Antonelli, M., Penfold, R. S., Canas, L. D. S., Sudre, C., Rjoob, K., Murray, B., … Steves, C. (2023). SARS-CoV-2 infection following booster vaccination: Illness and symptom profile in a prospective, observational community-based case-control study. Journal of Infection, 87(6), 506–515.
Bhattacharya, A., Ranjan, P., Ghosh, T., Agarwal, H., Seth, S., Maher, G. T., … Wig, N. (2021). Evaluation of the dose-effect association between the number of doses and duration since the last dose of COVID-19 vaccine, and its efficacy in preventing the disease and reducing disease severity: A single centre, cross-sectional analytical study from India. Diabetes & Metabolic Syndrome, 15(5), 102238.
Blakeway, H., Prasad, S., Kalafat, E., Heath, P. T., Ladhani, S. N., Le Doare, K., … Khalil, A. (2022). COVID-19 vaccination during pregnancy: Coverage and safety. American Journal of Obstetrics and Gynecology, 226(2), 236.e1–236.e14.
Dayan, S. (2021). COVID-19 ve aşı. Dicle Tıp Dergisi, 48, 98–113.
Duarte, L. F., Gálvez, N. M. S., Iturriaga, C., Melo-González, F., Soto, J. A., Schultz, B. M., … Kalergis, A. M. (2021). Immune profile and clinical outcome of breakthrough cases after vaccination with an inactivated SARS-CoV-2 vaccine. Frontiers in Immunology, 12, 742914.
Estofolete, C. F., Banho, C. A., Campos, G. R. F., Marques, B. C., Sacchetto, L., Ullmann, L. S., … Nogueira, M. L. (2021). Case study of two post vaccination SARS-CoV-2 infections with P.1 variants in CoronaVac vaccinees in Brazil. Viruses, 13(7), 1237.
Fu, W., Sivajohan, B., McClymont, E., Albert, A., Elwood, C., Ogilvie, G., & Money, D. (2022). Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants. International Journal of Gynecology & Obstetrics, 156(3), 406–417.
Girardi, G., & Bremer, A. A. (2022). Scientific evidence supporting coronavirus disease 2019 (COVID-19) vaccine efficacy and safety in people planning to conceive or who are pregnant or lactating. Obstetrics & Gynecology, 139(1), 3–8.
Gryszczyńska, B., Budzyń, M., Grupińska, J., Kasprzak, M. P., & Gryszczyńska, A. (2022). Nutritional behaviors, vitamin supplementation and physical activity among Polish adults during the COVID-19 pandemic. Nutrients, 14(2), 331.
Hamulka, J., Jeruszka-Bielak, M., Górnicka, M., Drywień, M. E., & Zielinska-Pukos, M. A. (2020). Dietary supplements during COVID-19 outbreak: Results of Google Trends analysis supported by PLifeCOVID-19 online studies. Nutrients, 13(1), 54.
Joubert, E., Kekeh, A. C., & Amin, C. N. (2022). COVID-19 and novel mRNA vaccines in pregnancy: An updated literature review. BJOG: An International Journal of Obstetrics and Gynaecology, 129(1), 21–28.
Kalafat, E., O’Brien, P., Heath, P. T., Le Doare, K., von Dadelszen, P., Magee, L., … Khalil, A. (2021). Benefits and potential harms of COVID-19 vaccination during pregnancy: Evidence summary for patient counseling. Ultrasound in Obstetrics & Gynecology, 57(5), 681–686.
Karbownik, M. S., Dobielska, M., Paul, E., Kowalczyk, R. P., & Kowalczyk, E. (2021). Health-, medication- and dietary supplement-related behaviors and beliefs relatively unchanged during the COVID-19 pandemic lockdown. Research in Social and Administrative Pharmacy, 17(8), 1501–1506.
Korkmaz, S., Ateşçelik, M., Balcı, H. N., Baykara, S., Canpolat, Ş., Korkmaz, H., & Atmaca, M. (2022). Health anxiety, health perception, and healthy lifestyle behavior among psychiatric patients during the COVID-19 pandemic. The Primary Care Companion for CNS Disorders, 24(2), 21m03197.
Macit, M. S. (2020). Covid-19 salgını sonrası yetişkin bireylerin beslenme alışkanlıklarındaki değişikliklerin değerlendirilmesi. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 13(3), 277–288.
Magon, N., Prasad, S., Mahato, C., & Sharma, J. B. (2022). COVID-19 vaccine and pregnancy: A safety weapon against pandemic. Taiwanese Journal of Obstetrics & Gynecology, 61(2), 201–209.
McKenna, M. J., Lyons, O. C., Flynn, M. A., Crowley, R. K., Twomey, P. J., & Kilbane, M. T. (2022). COVID-19 pandemic and vitamin D: Rising trends in status and in daily amounts of vitamin D provided by supplements. BMJ Open, 12(8), e059477.
Merwid-Ląd, A., Szandruk-Bender, M., Matuszewska, A., Trocha, M., Nowak, B., Oster, M., & Szeląg, A. (2022). Factors that influence the use of dietary supplements among the students of Wroclaw Medical University in Poland during the COVID-19 pandemic. International Journal of Environmental Research and Public Health, 19(12), 7485.
Mun, H., & So, E. S. (2022). Changes in physical activity, healthy diet, and sleeping time during the COVID-19 pandemic in South Korea. Nutrients, 14(5), 960.
Puścion-Jakubik, A., Bielecka, J., Grabia, M., Mielech, A., Markiewicz-Żukowska, R., Mielcarek, K., … Socha, K. (2021). Consumption of food supplements during the three COVID-19 waves in Poland—Focus on zinc and vitamin D. Nutrients, 13(10), 3361.
Rottenstreich, M., Sela, H. Y., Rotem, R., Kadish, E., Wiener-Well, Y., & Grisaru-Granovsky, S. (2022). Covid-19 vaccination during the third trimester of pregnancy: Rate of vaccination and maternal and neonatal outcomes, a multicentre retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 129(2), 248–255.
Selçuk, K. T., & Şahin, N. (2021). COVID-19 salgını sürecinde yetişkinlerde gıda takviyesi kullanımı ve ilişkili etmenler. TJFMPC, 15(4), 751–762.
Shimabukuro, T. T., Kim, S. Y., Myers, T. R., Moro, P. L., Oduyebo, T., Panagiotakopoulos, L., … CDC v-safe COVID-19 Pregnancy Registry Team. (2021). Preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons. The New England Journal of Medicine, 384(24), 2273–2282.
Singh, C., Naik, B. N., Pandey, S., Biswas, B., Pati, B. K., Verma, M., & Singh, P. K. (2021). Effectiveness of COVID-19 vaccine in preventing infection and disease severity: A case-control study from an Eastern State of India. Epidemiology and Infection, 149, e224.
Stock, S. J., Carruthers, J., Calvert, C., Denny, C., Donaghy, J., Goulding, A., … Wood, R. (2022). SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nature Medicine, 28(3), 504–512.
Tudisco, R., Garufi, C., Rizzo, F., Polimeno, T., Lanzone, A., & De Carolis, S. (2023). Impact of mRNA-based vaccines in the prevention of adverse outcomes of COVID-19 infection in pregnancy: A single-center cohort study. Frontiers in Pediatrics, 11, 1214768.
World Health Organization. (2022). Questions and answers: COVID-19 vaccines and pregnancy (Erişim tarihi: 15 Aralık 2023). https://www.who.int/publications/i/item/WHO-2019-nCoV-FAQ-Pregnancy-Vaccines-2022.1
World Health Organization. (2022). Country readiness for COVID-19 vaccines (Erişim tarihi: 15 Kasım 2023). https://www.who.int/news-room/feature-stories/detail/country-readiness-for-COVID-19-vaccines
Wróbel, K., Milewska, A. J., Marczak, M., & Kozłowski, R. (2021). The impact of the COVID-19 pandemic on the composition of dietary supplements and functional foods notified in Poland. International Journal of Environmental Research and Public Health, 18(22), 11751.
Yavuz, E. (2020). COVID-19 aşıları. Türkiye Aile Hekimliği Dergisi, 24(4), 223–234.
Zawbaa, H. M., Osama, H., El-Gendy, A., Saeed, H., Harb, H. S., Madney, Y. M., … Abdelrahim, M. E. A. (2022). Effect of mutation and vaccination on spread, severity, and mortality of COVID-19 disease. Journal of Medical Virology, 94(1), 197–204.
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