THE ROLE OF POLYMORPHIC VARIANTS OF DNA REPAIR GENES XRCC1, XPA AND XPD IN THE DEVELOPMENT OF RESISTANCE OF MUSCLE-NON-INVASIVE BLADDER CANCER

Л.З. Булякбаева; Д.Р. Муртазина; К.И Мухаметьянова; Научный руководитель; к. б. н доцент; С.М Измайлова

THE ROLE OF POLYMORPHIC VARIANTS OF DNA REPAIR GENES XRCC1, XPA AND XPD IN THE DEVELOPMENT OF RESISTANCE OF MUSCLE-NON-INVASIVE BLADDER CANCER

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Authors

Л.З. Булякбаева Кафедра биологии, Башкирский государственный медицинский университет, г. Уфа
Д.Р. Муртазина Кафедра биологии, Башкирский государственный медицинский университет, г. Уфа
К.И Мухаметьянова Кафедра биологии, Башкирский государственный медицинский университет, г. Уфа
Научный руководитель Кафедра биологии, Башкирский государственный медицинский университет, г. Уфа
к. б. н доцент Кафедра биологии, Башкирский государственный медицинский университет, г. Уфа
С.М Измайлова Кафедра биологии, Башкирский государственный медицинский университет, г. Уфа

Keywords:

bladder cancer, polymorphic variants, repair genes

Abstract

Bladder cancer (BC) is a pressing problem in oncology. To assess the contribution of DNA repair genes to the development of the risk of recurrence of muscular-non-invasive bladder diseases (MNIBC), genotypes and alleles of polymorphic loci c.839G> A and c.1196A> G of the XRCC1 gene, c.2251A> C of the XPD and C -4A> G gene of the XPA. It has been revealed that polymorphic variants of excision repair genes for nucleotides and bases of XRCC1 and XPD DNA are statically associated with the risk of recurrence of MNIBC. Polymorphic variants of DNA excision repair genes XRCC1 and XPD of nucleotides and bases are statically associated with the risk of resistance of MNIBC. Thus, we have currently developed methods of early diagnostics of BC using molecule-genetic markers determining further tumour development.
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Published

2022-07-02

How to Cite

Булякбаева, Л., Муртазина, Д., Мухаметьянова, К., руководитель, Н., доцент, к. б. н., & Измайлова, С. (2022). THE ROLE OF POLYMORPHIC VARIANTS OF DNA REPAIR GENES XRCC1, XPA AND XPD IN THE DEVELOPMENT OF RESISTANCE OF MUSCLE-NON-INVASIVE BLADDER CANCER. GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES, 2(2), 1–4. Retrieved from https://gevhernesibedergisi.com/index.php/gnj/article/view/3