Does the Use of Low Molecular Weight Heparin Affect Pregnancy Screening Test Results?

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  • Ali GÜRSOY Maltepe University



First Pregnancy Trimester, Low Molecular Weight Heparin, Maternal Serum Screening Tests, Neural Tube Defects


Objective: Low molecular weight heparin, also known as LMWH, is a drug that is frequently utilized in the treatment of venous thromboembolism risk management as well as the prevention of potential miscarriages in pregnancy. Our study sought to answer the question of whether or not the use of LMWH, which is becoming increasingly popular as a treatment option in clinical settings, has an impact on the outcomes of screening tests administered during the first trimester of pregnancy as well as tests intended to detect birth defects in the neural tube.

Methods: This retrospective case-control study included pregnant women who had a first trimester screening test and a neural tube defect screening test during pregnancy follow-up. A comparison was made between fifty-three pregnant women using LMWH and three hundred twenty-five pregnant women not using LMWH. Serum beta human chorionic gonadotropin (beta-hCG), placenta associated plasma protein-A (PAPP-A), and alpha-fetoprotein (AFP) levels were investigated in this study.

Results: Patients included in the study ranged in age from 20 to 47 years. In terms of first trimester screening test markers PAPP-A, PAPP-A multiples of the media (MoM), beta-hCG, beta-hCG MoM, and neural tube defect markers AFP, AFP MoM (p> 0.05), there was no significant difference between the control group and LMWH group (p> 0.05).

Conclusion: Our study has shown that the use of LMWH during pregnancy does not cause misinterpretation of first trimester screening test and neural tube defect screening tests. Further studies with larger samples are required to confirm our findings.


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How to Cite

GÜRSOY, A. (2023). Does the Use of Low Molecular Weight Heparin Affect Pregnancy Screening Test Results? . GEVHER NESIBE JOURNAL OF MEDICAL AND HEALTH SCIENCES, 8(1), 91–96.